Regulation of Drosophila life span by olfaction and food-derived odors.
نویسندگان
چکیده
Smell is an ancient sensory system present in organisms from bacteria to humans. In the nematode Caenorhabditis elegans, gustatory and olfactory neurons regulate aging and longevity. Using the fruit fly, Drosophila melanogaster, we showed that exposure to nutrient-derived odorants can modulate life span and partially reverse the longevity-extending effects of dietary restriction. Furthermore, mutation of odorant receptor Or83b resulted in severe olfactory defects, altered adult metabolism, enhanced stress resistance, and extended life span. Our findings indicate that olfaction affects adult physiology and aging in Drosophila, possibly through the perceived availability of nutritional resources, and that olfactory regulation of life span is evolutionarily conserved.
منابع مشابه
Libert , Food - Derived Odors Life Span by Olfaction andDrosophilaRegulation
http://www.sciencemag.org/cgi/content/full/315/5815/1133 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1136610/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.s...
متن کاملFood - Derived Odors Life Span by Olfaction andDrosophilaRegulation
www.sciencemag.org (this information is current as of March 13, 2007 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/315/5815/1133 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1136610/DC1 can be found at: ...
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عنوان ژورنال:
- Science
دوره 315 5815 شماره
صفحات -
تاریخ انتشار 2007